The effects of prolactin (PRL), growth hormone (GH) and luteinizing hormone (LH) on testicular LH receptor concentration and on testosterone synthesis in response to LH (testicular responsiveness) was studied in mature intact and hypophysectomized rats. Hypophysectomy reduced LH receptor concentration by 80 o/o and testicular responsiveness to LH by 70a/o , 7 days after surgery. Daily treatment...

the cyclical changes in the gonadotropins stimulate ovarian follicular development either to the ovulatory stage or to undergo atresia. one such intrafollicular factor may be inter-cellular communication via gap junctions. we have examined the effects of two agents (retinoids and alkanols), known to disrupt or uncouple gap junction, on fsh-stimulated lh receptor induction and progestrone synthe...

Introduction: Stimulation or inactivation of the lateral hypothalamus (LH) produces antinociception. Studies showed a role for the ventral tegmental area (VTA) in the antinociception induced by LH chemical stimulation through the orexinergic receptors. In this study, we assessed the role of intra-VTA dopamine D1 and D2 receptors in antinociceptive effects of cholinergic agonist, carbachol, m...

Background: Polycystic ovary syndrome (PCOS) is a common complex genetic endocrinopathy, affecting 5 - 10% of women at reproductive age. PCO granulosa cells seem to have abnormal responses to follicle- stimulating hormone (FSH). FSH is considered to be a pituitary glycoprotein that plays an important role during folliculogenesis as it promotes the proliferation and differentiation of granulosa ...

A specific luteinizing hormone receptor (LHR) mRNA binding protein (LRBP) has been identified and purified. This LH receptor mRNA binding protein selectively binds to the polypyrimidine rich bipartite sequence in the coding region of the LHR mRNA and accelerates its degradation. In response to preovulatory LH surge, the LH receptor expression in the ovary undergoes downregulation by accelerated...

Gonadotropin-releasing hormone (GnRH) 1 and 2 and luteinizing hormone (LH) receptors have been described in the gastrointestinal tract. We have previously demonstrated antibodies in serum against GnRH1 in patients with gastrointestinal dysfunction and diabetes mellitus, and antibodies against GnRH receptor, LH, and LH receptor in patients with infertility. The aim of this study was to search fo...